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High Qualty Vardenafil & Tadalafil

Basic Info

Model No.:  TDLF

Product Description

Model NO.: TDLF

Certification: GMP

Type: Chemical Reagent

Volatile: Not Volatile

Specification: Medicine grade

Function: Hormones and Regulation of Endocrine Function of Drug

Grade Standard: Medicine Grade

State: Solid

Trademark: Fraken

Origin: China


CAS No.: 171596-29-5

Molecular Formula: C22H23N3O3

Density 1.4g/cm3
Boiling point 569.9°C at 760 mmHg
Refractive index 1.705
Flash point 298.5°C
Vapour Pressur 5.29E-13mmHg at 25°C

Tadalafil is an oral drug that is used for treating impotence (the inability to attain or maintain a penile erection) and benign prostatic hyperplasia (BPH). It is in a class of drugs called phosphodiesterase-5 (PDE5) inhibitors that also includes and vardenafil .Erection of the penis is caused by the filling of the penis with blood. Filling occurs because the blood vessels that bring blood to the penis increase in size and deliver more blood to the penis, and, at the same time, the blood vessels that take blood away from the penis decrease in size and remove less blood from the penis. Sexual stimulation that leads to an erection causes the production and release of nitric oxide in the penis. The nitric oxide causes an enzyme, guanylate cyclase, to produce cyclic guanosine monophosphate (cGMP). It is cGMP that is primarily responsible for increasing and decreasing the size of blood vessels carrying blood to and from the penis, respectively, and causing an erection. When the cGMP is destroyed by another enzyme, phosphodiesterase-5, the blood vessels return to their normal size, blood leaves the penis, and the erection ends. Tadalafil prevents phosphodiesterase-5 from destroying cGMP so that cGMP stays around longer. The persistence of cGMP leads to a more prolonged engorgement of the penis with blood.


1.CAS: 171596-29-5

2.MF: C22H19N3O4

3.MW: 389.4

4.Properties:White Powder

5.Usage :pharmaceutical raw materials, the hormone

6.Assay: 99%

7.Package: 1KG/bag (special packing)

Melting point 230-235ºC
Boiling point 692.2°C at 760 mmHg
Flash point 372.5°C
Vapour Pressur 5.17E-19mmHg at 25°C

Vardenafil (INN) is a PDE5 inhibitor used for treating erectile dysfunction, primarily by specific inhibition of PDE-5 enzyme activity play a role in making the treatment of penile erection. The drug compared with similar products, with fast onset, sustained efficacy of a reliable, high-quality erection as well as better security and so on. Taking vardenafil clinical report showed that after 15 minutes from 35% efficiency, 30 minutes ~ 1 hour and up to 81% efficient, equivalent to a half-life . Vardenafil and (tadalafil) compared to PDE-5 inhibitor in the role of the advantages and disadvantages: PDE-5 inhibitor tadalafil IC50 of 0.9nM `~ 6.7nM for , vardenafil the IC50 for 0.1Nm ~ 0.7nM. Clearly, vardenafil on PDE-5 inhibition of the ability of the 5 times . PDE-5 inhibitor with other PDE isoenzymes (such as PDE1 ~ 4, PDE7 ~ 10 and PDE-5) the selective binding capacity without too much difference, but there are PDE-6.

High Qualty Vardenafil & Tadalafil

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